Textbook of Pharmaceutical Chemistry

Description

Pharmaceutical (medicinal) chemistry is concerned with the design (drug design) and synthesis of biologically active molecules. The aim is to gain new chemical molecules that could enable the discovery of new pharmaceuticals or optimize already known drug structures, thereby to expand the portfolio of chemical drugs. Medicinal chemistry is discipline at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents, or bio-active molecules (drugs). Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products. Compounds used as medicines are overwhelmingly organic compounds including small organic molecules and biopolymers. However, inorganic compounds and metal-containing compounds have been found to be useful as drugs. For example, the cis-platin series of platinium-containing complexes have found use as anti-cancer agents. Medicinal chemistry is a highly interdisciplinary science combining organic chemistry with biochemistry, computational chemistry, pharmacology, pharmacognosy, molecular biology, statistics, and physical chemistry. This book may useful not only for the students and teachers of pharmacy but also beneficial for medical students as well.