Dynamics of Mtdna Heteroplasmy in Human Diseases

Description

Mitochondrial heteroplasmy is the co-expression of inherited polymorphisms and somatic mutations in different proportions in each person's mitochondrial DNA genome, which repeats in patterns that are specific to each type of tissue. A classic theory says that carcinogenic cellular processes involve significant changes in the normal way mitochondria work, such as dependence on aerobic and anaerobic glycolysis and abnormal production and release of Lactate. The current review emphasizes the need to set up crucial focuses to investigate the many biological functions that mitochondrial heteroplasmy plays in cancer biology within the translational context of human health and illness.