Pharmaceutical Dosage Forms and Drug Delivery Systems

Description

The drug delivery system deals with the pharmaceutical formulation of the drug and the dynamic interactions among the drug, its formulation matrix, its container, and the physiologic milieu of the patient. These dynamic interactions are the subject of pharmaceutics. Rheology is the study of the flow of matter, primarily in the liquid state, but also as 'soft solids' or solids under conditions in which they respond with plastic flow rather than deforming elastically in response to an applied force. It applies to substances which have a complex microstructure, such as muds, sludges, suspensions, polymers and other glass formers (e.g., silicates), as well as many foods and additives, bodily fluids (e.g., blood) and other biological materials or other materials which belong to the class of soft matter. Speed and productivity are mission critical in Pharmaceutical Development. Longterm survival and success in the drug development space will go to those players who figure out how to get promising new products to market quickly while simultaneously controlling development costs. Critical chain provides pieces to the solution not found in traditional project management. Adverse effects can occur as a collateral or side effect of many interventions, but they are particularly important in pharmacology, due to its wider, and sometimes uncontrollable, use by way of self-medication. Thus, responsible drug use becomes an important issue here. Adverse effects, like therapeutic effects of drugs, are a function of dosage or drug levels at the target organs, so they may be avoided or decreased by means of careful and precise pharmacokinetics, the change of drug levels in the organism in function of time after administration. The integrated approach of this book not only provides a singular perspective of the overall field, but also supplies a unified source of information for students, instructors and professionals.