Textbook of Transgenic Animals and Cloning

Description

Transgenesis is a process of incorporation of foreign DNA in to cellular genome. Once introduced into the cell, exogenous DNA can be processed by either of the two pathways operating in the cell, i.e. Non-homologous end joining (NHEJ) or Homologous recombination (HR), resulting into two different outcomes of the exogenous DNA. The former leads to random integration of exogenous DNA in the cellular genome where as the later scans for homology between the exogenous and cellular DNA and targets the exogenous DNA to precise locations resulting in targeted integration. Transgenic animals are specially designed to study the role of genes in the development of certain diseases. Moreover, in order to devise a cure for these diseases, the transgenic animals are used as model organisms. These transgenic models are used in research for the development of medicines.Animal Transgenesis and Cloning is a concise, balanced introduction to this dynamic subject, covering key issues and current techniques currently used in animal transgenesis and cloning. This book “Textbook of Transgenic Animals and Cloning” provide the reader with the essentials of the subject, from the molecular basis of gene structure and function to therapeutic gene cloning in humans, social and ethical implications of this important area of research are also considered.